منابع مشابه
Toll-free autoimmunity
Proteins secreted by parasite eggs might hold the key to the next antiinflammatory therapy. On page 1319, Smith and colleagues describe the first chemokine binding protein (CKBP) produced by a human pathogen and show that it can suppress acute inflammation in disease models. The blood-dwelling worm Schistosoma mansoni takes advantage of the host’s immune system in two ways. It subverts specific...
متن کاملEndosomal Toll-like receptors in autoimmunity: mechanisms for clinical diversity.
The endosomal Toll-like receptors (TLR3, TLR7 and TLR9) have been implicated in the pathogenesis of autoimmune diseases. Their signaling pathways show remarkable similarities and yet the outcomes following activation of each of these TLRs lead to clinically distinct autoimmune disease phenotypes. This review discusses how differences may arise at a molecular and cellular level to account for th...
متن کاملStimulation of autoimmunity by toll-like receptor ligands.
H ealthy individuals are known to harbour self-specific T cells against a variety of immunodominant selfpeptides—for example, myelin-basic protein (MBP) peptides. Yet, autoimmunity in a given individual is a rare event indicating that the self-reactive cells are somehow prevented from inflicting damage. Various experiments in which transgenic animals express both peripheral antigen and its cogn...
متن کاملAntigen-Presenting Cells and their Fc and Toll-Like Receptors: Leading Suspects in Autoimmunity
Antigen-presenting cells (APCs) play an important role in the development of autoimmune diseases. These cells recognize pathogen associated molecular patterns but also endogenously produced ligands through toll-like receptors (TLRs). Aberrant activation of these receptors and the following intracellular signaling pathways can induce the deleterious production of pro-inflammatory cytokines. In g...
متن کاملRole of Toll like receptor-activated dendritic cells in the development of autoimmunity.
The recognition of microbial stimuli by Toll-like receptors (TLRs) expressed on dendritic cells (DCs) is essential for the regulation of immune responses. DC activation via TLRs leads to the production of proinflammatory cytokines, chemokines and surface molecules that play a key role in the regulation and control of inflammatory reactions and adaptive immunity. Minor imbalances in the feedback...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2005
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem20210iti4